Ethanethiol → HCID 59676117, compound

HRID 624509Notes

Reaction equation

HRID 624509 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:16])[C:11]1[C:6]2=[CH:7][CH:8]=[C:9]2[N:19]([CH3:20])[N:18]=[CH:17][C:10]2=1.[Al+3].[Cl-].[Cl-].[Cl-].CCS.C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH3:20][N:19]1[C:9]2=[CH:8][CH:7]=[C:6]3[C:11]([N:12]([CH3:16])[C:13]4[C:5]3=[CH:4][C:3]([OH:2])=[CH:15][CH:14]=4)=[C:10]2[CH:17]=[N:18]1

Participants

6

Reactant 4

HCID 6343EthanethiolHCID 516892Sodium BicarbonateHCID 6451240Aluminum(III) ChlorideHCID 59676069HCID 59676069, compound

Product 1

HCID 59676117HCID 59676117, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 7-methoxy-3,10-dimethyl-3,10-dihydro-2,3,10-triaza-cyclopenta[a]fluorene (55 mg, 0.21 mmol), AlCl3 (0.84 mmol, 4.0 eq.) and EtSH (0.63 mmol, 3.0 eq.) in CH2Cl2 (2 mL) was stirred at room temperature for 16 hours. The reaction mixture was poured into cold saturated NaHCO3 solution, extracted with CH2Cl2, washed with brine and dried, concentrated to yield the crude product. The crude product was then purified by chromatography to yield the title compound as a white solid.

Workup

  1. extractionextracted with CH2Cl2
  2. washwashed with brine
  3. customdried
  4. concentrationconcentrated
  5. customto yield the crude product
  6. customThe crude product was then purified by chromatography

Sources & evidence

ORD record
ord-82b8cc28527740908499233c0153c362
Source dataset
uspto-grants-2016_04
Patent number
US09303037B2

Reaction notes

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