反应详情

温度

170 °C

In a 500 mL round bottom flask, the uniform mixture of 2-amino-4-chlorobenzaldehyde (16 g, 103.2 2 mmol) and urea (123.8 g, 2063 mmol) was heated at 170° C. with vigorous stirring for 2 h. On completion of reaction, the reaction mixture was cooled to rt and diluted with ice-cold water. The solid that formed was collected by filtration and washed with ice-cold water. The solid was dried under reduced pressure to give crude 7-chloroquinazolin-2-ol as a yellow solid. Yield: 19 g. LCMS (ESI, m/z): 181 (M+1)+

1. customOn completion of reaction
2. temperaturethe reaction mixture was cooled to rt
3. additiondiluted with ice-cold water
4. customThe solid that formed
5. filtrationwas collected by filtration
6. washwashed with ice-cold water
7. customThe solid was dried under reduced pressure