反应详情

To a mixture of tert-butyl 3-(3-(3-fluoro-4-(methylcarbamoyl)phenyl)pyrazin-2-yl)azetidine-1-carboxylate (5.19 g, 13.43 mmol) and DCM (20 mL) was added 2,2,2-trifluoroacetic acid (7.24 mL, 94 mmol). The mixture was stirred at rt for 1 h. The mixture was concentrated in vacuo. DCM was added and evaporated to remove extra TFA. Ether was added and evaporated. The product was obtained as a yellow oil after drying on vacuum overnight. MS: 287 (M+1).

1. concentrationThe mixture was concentrated in vacuo
2. additionDCM was added
3. customevaporated
4. customto remove extra TFA
5. additionEther was added
6. customevaporated
7. customThe product was obtained as a yellow oil
8. customafter drying on vacuum overnight