5-Chloro-2-furaldehyde → HCID 86722896, compound

HRID 624570Notes

Reaction equation

HRID 624570 reaction equation
[OH:1][C@@H:2]([CH3:24])[CH2:3][N:4]1[C:12]([C:13]2[CH:14]=[C:15]([CH3:19])[CH:16]=[CH:17][CH:18]=2)=[C:11]2[C:6]([N:7]([CH3:23])[C:8](=[O:22])[N:9]([CH3:21])[C:10]2=[O:20])=[CH:5]1.[Cl:25][C:26]1[O:30][C:29]([CH:31]=O)=[CH:28][CH:27]=1>>[Cl:25][C:26]1[O:30][C:29]([C@@H:31]2[C:5]3=[C:6]4[N:7]([CH3:23])[C:8](=[O:22])[N:9]([CH3:21])[C:10](=[O:20])[C:11]4=[C:12]([C:13]4[CH:14]=[C:15]([CH3:19])[CH:16]=[CH:17][CH:18]=4)[N:4]3[CH2:3][C@H:2]([CH3:24])[O:1]2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 27696305-Chloro-2-furaldehydeHCID 86722897HCID 86722897, compound

Product 1

HCID 86722896HCID 86722896, compound

Procedure

The title compound was prepared from (S)-6-(2-hydroxypropyl)-1,3-dimethyl-5-m-tolyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione and 5-chlorofuran-2-carbaldehyde by an analogous method to Example 12. Purification was carried out by chromatography on silica eluting with 0-55% EtOAc in iso-hexane;

Workup

  1. customPurification

Sources & evidence

ORD record
ord-27665d7bd57f42b78ec2446670726b20
Source dataset
uspto-grants-2016_04
Patent number
US09303035B2

Reaction notes

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