HRID624576

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15141964

2-Bromo-4-chloro-1,3-thiazole

C3HBrClNS

结构：CON(C)C(=O)COC(CO[Si](C)(C)C(C)(C)C)Cn1cc2c(c1-c1cccc(C#N)c1)c(=O)n(C)c(=O)n2C

HCID86722900

未命名化合物

PRODUCTS

生成物

结构：Cn1c(=O)c2c(-c3cccc(C#N)c3)n(CC(CO[Si](C)(C)C(C)(C)C)OCC(=O)c3nc(Cl)cs3)cc2n(C)c1=O

HCID86722902

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 2-((1-((tert-butyldimethylsilyl)oxy)-3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)propan-2-yl)oxy)-N-methoxy-N-methylacetamide and 2-bromo-4-chlorothiazole analogously to Example 13, step 3;

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ec753dc587ac4f639a9aed6737f7cf90
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09303035B2
来源说明: uspto-grants-2016_04

反应 SMILES

[Si:1]([O:8][CH2:9][CH:10]([O:33][CH2:34][C:35](N(OC)C)=[O:36])[CH2:11][N:12]1[C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]#[N:28])[CH:22]=2)=[C:19]2[C:14]([N:15]([CH3:32])[C:16](=[O:31])[N:17]([CH3:30])[C:18]2=[O:29])=[CH:13]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Br[C:42]1[S:43][CH:44]=[C:45]([Cl:47])[N:46]=1>>[Si:1]([O:8][CH2:9][CH:10]([O:33][CH2:34][C:35]([C:42]1[S:43][CH:44]=[C:45]([Cl:47])[N:46]=1)=[O:36])[CH2:11][N:12]1[C:20]([C:21]2[CH:22]=[C:23]([CH:24]=[CH:25][CH:26]=2)[C:27]#[N:28])=[C:19]2[C:14]([N:15]([CH3:32])[C:16](=[O:31])[N:17]([CH3:30])[C:18]2=[O:29])=[CH:13]1)([C:4]([CH3:6])([CH3:7])[CH3:5])([CH3:2])[CH3:3]