3-Methylbenzoyl chloride → 6-(2-Aminoethyl)-1,3-dimethyl-5-(m-tolyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

HRID 624591Notes

Reaction equation

HRID 624591 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11]2[C:6]([N:7]([CH3:22])[C:8](=[O:21])[N:9]([CH3:20])[C:10]2=[O:19])=[CH:5]1.[CH3:23]C1C=C(C=CC=1)C(Cl)=O>>[NH2:1][CH2:2][CH2:3][N:4]1[C:12]([C:13]2[CH:18]=[C:17]([CH3:23])[CH:16]=[CH:15][CH:14]=2)=[C:11]2[C:6]([N:7]([CH3:22])[C:8](=[O:21])[N:9]([CH3:20])[C:10]2=[O:19])=[CH:5]1

Participants

3

Reactant 2

HCID 743753-Methylbenzoyl chlorideHCID 867228796-(2-Amino-ethyl)-1,3-dimethyl-5-phenyl-1,6-dihydro-pyrrolo[3,4-d]pyrimidine-2,4-dione

Product 1

HCID 867229126-(2-Aminoethyl)-1,3-dimethyl-5-(m-tolyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Procedure

This compound was prepared analogously to Intermediate A by replacing benzoyl chloride (step 2) with 3-methylbenzoyl chloride (commercial).

Sources & evidence

ORD record
ord-56dd3a7c86b04ba3b33484f107cd153c
Source dataset
uspto-grants-2016_04
Patent number
US09303035B2

Reaction notes

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