Tetrabutylammonium Fluoride → 5-(3-fluorophenyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Temperature

60 °C

Tetra-n-butylammonium fluoride solution (1.0M, 24.8 mL, 24.8 mmol) was added to a suspension of 5-(3-fluorophenyl)-1,3-dimethyl-6-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1.00 g, 2.48 mmol) in THF (7 mL), and the mixture was stirred at 60° C. for 2 hours, then cooled to room temperature and stirred for 4 hours. The mixture was concentrated under vacuum and the residue was dissolved in ethyl acetate (50 mL). The mixture was washed with water (3×25 mL) and brine (1×25 mL). The organic phase was dried over magnesium sulfate and the solvent was evaporated under vacuum to afford the title compound.

1. temperaturecooled to room temperature
2. stirringstirred for 4 hours
3. concentrationThe mixture was concentrated under vacuum
4. dissolutionthe residue was dissolved in ethyl acetate (50 mL)
5. washThe mixture was washed with water (3×25 mL) and brine (1×25 mL)
6. dry with materialThe organic phase was dried over magnesium sulfate
7. customthe solvent was evaporated under vacuum

ORD record

ord-99aea9858ce24ffe828e1b95f0542584

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09303035B2