2-Iodo-4-methyl-1,3-thiazole → 1,3-dimethyl-5-(4-methylthiazol-2-yl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

HRID 624611Notes

Reaction equation

HRID 624611 reaction equation
[CH3:1][N:2]1[C:7]2=[CH:8][NH:9][C:10]([C:11]3C=C(C=CC=3)C#N)=[C:6]2[C:5](=[O:19])[N:4]([CH3:20])[C:3]1=[O:21].IC1[S:24][CH:25]=[C:26]([CH3:28])[N:27]=1>>[CH3:1][N:2]1[C:7]2=[CH:8][NH:9][C:10]([C:11]3[S:24][CH:25]=[C:26]([CH3:28])[N:27]=3)=[C:6]2[C:5](=[O:19])[N:4]([CH3:20])[C:3]1=[O:21]

Participants

3

Reactant 2

HCID 231545942-Iodo-4-methyl-1,3-thiazole2×HCID 867229283-(1,3-Dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Product 1

HCID 1363483951,3-dimethyl-5-(4-methylthiazol-2-yl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Procedure

The title compound was prepared by an analogous method to 3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile (Intermediate Ga) by replacing 3-bromobenzonitrile (step 3) with 2-iodo-4-methylthiazole (Intermediate F).

Sources & evidence

ORD record
ord-dd01b60a359c4983a6ade2779415235c
Source dataset
uspto-grants-2016_04
Patent number
US09303035B2

Reaction notes

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