N-bromobutanimide → Ethyl 2-(4-bromo-1H-pyrazol-1-yl)-2-methylpropanoate

HRID 624633Notes

Reaction equation

HRID 624633 reaction equation
[CH3:1][C:2]([N:9]1[CH:13]=[CH:12][CH:11]=[N:10]1)([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[Br:14]N1C(=O)CCC1=O>CC1CCCO1>[Br:14][C:12]1[CH:11]=[N:10][N:9]([C:2]([CH3:1])([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH:13]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 90403665Ethyl 2-methyl-2-(1H-pyrazol-1-yl)propanoate

Product 1

HCID 59231678Ethyl 2-(4-bromo-1H-pyrazol-1-yl)-2-methylpropanoate

Reagents, catalysts & solvents 1

HCID 73012-MethyltetrahydrofuranSolvent

Procedure

Ethyl 2-methyl-2-(1H-pyrazol-1-yl)propanoate 17 was reacted with N-bromosuccinimide (NBS) in 2-methyltetrahydrofuran to give IV (CAS Reg. No. 1040377-17-0).

Sources & evidence

ORD record
ord-55db6961761c4f62836c3671cceaac5f
Source dataset
uspto-grants-2016_04
Patent number
US09303043B2

Reaction notes

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