1-Isopropylhydrazine hydrochloride → 9-Bromo-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine

HRID 624641Notes

Reaction equation

HRID 624641 reaction equation
[Br:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]3[N:7]([CH:11]=[C:12]([C:14]([NH:16][C:17](=[NH:19])[CH3:18])=O)[N:13]=3)[CH2:8][CH2:9][O:10][C:4]=2[CH:3]=1.Cl.[CH:23]([NH:26]N)([CH3:25])[CH3:24]>C(O)(=O)C>[Br:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]3[N:7]([CH:11]=[C:12]([C:14]4[N:26]([CH:23]([CH3:25])[CH3:24])[N:19]=[C:17]([CH3:18])[N:16]=4)[N:13]=3)[CH2:8][CH2:9][O:10][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 855731-Isopropylhydrazine hydrochlorideHCID 1357436659-bromo-N-(1-iminoethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

Product 1

HCID 582043229-Bromo-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

9-Bromo-N-(1-iminoethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide 29 was reacted with isopropylhydrazine hydrochloride 4 in acetic acid to give III.

Sources & evidence

ORD record
ord-5d571b1286f942ebbc18b331a524c739
Source dataset
uspto-grants-2016_04
Patent number
US09303043B2

Reaction notes

Loading…