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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624653Generated: October 30, 2026

Hydrochloric Acid → HCID 90031490, compound

https://huagongshe.com/reaction/624653

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 90031146HCID 90031146—
SolventMethanol--water (1/1)HCID 22242641—
ProductHCID 90031490HCID 90031490—

Reaction Conditions

Temperature80 °C

Reaction Steps

To a solution of methyl 1-(pyrimidin-5-yl)-1H-indole-3-carboxylate (16 mg, 0.063 mmol) in water MeOH (316 μl) was added 2M KOH (158 μl, 0.316 mmol). The mixture was heated at 80° C. for 4 h then neutralized with 1M HCl. The precipitate was collected by filtration to afford the title compound as a white solid, which was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303045B2
Source datasetuspto-grants-2016_04
ORD IDord-d36b82add2bb4dd6825d02fd71a51c86
Source noteuspto-grants-2016_04