Hydrochloric Acid → HCID 90031490, compound

HRID 624653Notes

Reaction equation

HRID 624653 reaction equation
[N:1]1[CH:6]=[C:5]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([C:16]([O:18]C)=[O:17])=[CH:8]2)[CH:4]=[N:3][CH:2]=1.[OH-].[K+].Cl>O.CO>[N:3]1[CH:4]=[C:5]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([C:16]([OH:18])=[O:17])=[CH:8]2)[CH:6]=[N:1][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 90031146HCID 90031146, compound

Product 1

HCID 90031490HCID 90031490, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
80 °C

Procedure

To a solution of methyl 1-(pyrimidin-5-yl)-1H-indole-3-carboxylate (16 mg, 0.063 mmol) in water MeOH (316 μl) was added 2M KOH (158 μl, 0.316 mmol). The mixture was heated at 80° C. for 4 h then neutralized with 1M HCl. The precipitate was collected by filtration to afford the title compound as a white solid, which was used without further purification.

Workup

  1. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-d36b82add2bb4dd6825d02fd71a51c86
Source dataset
uspto-grants-2016_04
Patent number
US09303045B2

Reaction notes

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