HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624671Generated: October 25, 2026
Potassium Carbonate → Methyl 1-(2,2-difluoroethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
https://huagongshe.com/reaction/624671
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-1,1-difluoroethane | HCID 136186 | — |
| Reactant | methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate | HCID 21110084 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 1-(2,2-difluoroethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate | HCID 118436413 | — |
Reaction Steps
2-Bromo-1,1-difluoroethane (677 μl, 8.51 mmol) was added to a suspension of methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate (500 mg, 2.84 mmol) and K2CO3 (1177 mg, 8.51 mmol) in DMF (2838 μl) at RT. The mixture was heated at 70° C. for 14 h and purified by column chromatography (SiO2; DCM/MeOH) to afford the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303045B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-ed7eb43b7bcc470b81827e94d0aa7c07 |
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| Source note | uspto-grants-2016_04 |
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