反应详情

To a solution of (S)-4-(3-(3-cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl)-8-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]pyrazin-1-yl)benzoic acid (130 mg, 0.23 mmol) in DMF (2 mL) was added NH4Cl (37 mg, 0.69 mmol), TEA (93 mg, 0.92 mmol) and HATU (175 mg, 0.46 mmol). The mixture was stirred at RT overnight. After the reaction was completed, the solvent was evaporated and the residue was purified by Pre-TLC to give (S)-4-(3-(3-cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl)-8-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]pyrazin-1-yl)benzamide (60 mg, yield 46%).

1. customthe solvent was evaporated
2. customthe residue was purified by Pre-TLC