HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624775Generated: October 30, 2026
3-Chloroaniline → HCID 53240562, compound
https://huagongshe.com/reaction/624775
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Chloroaniline | HCID 7932 | — |
| Reactant | 5-Chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde | HCID 58196647 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 53240562 | HCID 53240562 | 11% |
Reaction Steps
To 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (177 mg, 0.75 mmol) in 1,4-dioxane was added 3-chloroaniline (397 μl, 3.75 mmol). The mixture was heated in microwave at 120° C. for 60 minutes. Precipitate was filtered off, and the filtrate was prepared by TLC (1% methanol/dichloromethane) to yield 26 mg (11% yield) of 5-(3-chlorophenylamino)-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde. LCMS (M+1=328)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303033B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-83bd87daf12c44f3bbf720c277ea20f1 |
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| Source note | uspto-grants-2016_04 |
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