Diisopropylethylamine → HCID 90203691, compound

HRID 624844Notes

Reaction equation

HRID 624844 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][NH:19][C:20]([CH3:23])([CH3:22])[CH3:21].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>>[C:20]([N:19]([CH3:18])[C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([CH3:23])([CH3:22])[CH3:21]

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 84552N-Methyl-tert-butylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 90203691HCID 90203691, compound

Procedure

In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid was reacted with N,2-dimethylpropan-2-amine (CAN 94896-77-2) in the presence of TBTU and DIEA to give the title compound as colorless oil; MS (EI): m/e=303.4 [MH+].

Sources & evidence

ORD record
ord-2a29856ce0e9485585b1fcc95e49f34b
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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