反应详情

The title compound was synthesized in analogy to Example 47 b), using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) and 3-methyl-1-(pyridazin-3-yl)butan-1-amine as starting materials. The product was isolated by chiral chromatography on Reprosil Chiral NR using a mixture of heptane, ethanol and 2-propanol as eluent. The (+)-enantiomer was isolated. MS (EI): m/e=432.5 [MH+].

1. customThe product was isolated by chiral chromatography on Reprosil Chiral NR
2. customThe (+)-enantiomer was isolated