HRID624925

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：Br.Br.c1ccc(CN2C[C@@H]3C[C@H]2CN3)cc1

HCID14612542

(1S,4S)-2-Benzyl-2,5-diazabicyclo[2.2.1]heptane--hydrogen bromide (1/2)

C12H18Br2N2

结构：O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1

HCID71087292

未命名化合物

PRODUCTS

生成物

结构：O=C(c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)N1C[C@@H]2C[C@H]1CN2Cc1ccccc1

HCID118451453

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with (1S,4S)-2-benzyl-2,5-diazabicyclo[2.2.1]heptane dihydrobromide (116258-17-4) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=455.7 [MH+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9fb0d8f8b610422c9bc45ffc947b165c
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09303012B2
来源说明: uspto-grants-2016_04

反应 SMILES

[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.Br.Br.[CH2:23]([N:30]1[CH2:35][C@@H:34]2[CH2:36][C@H:31]1[CH2:32][NH:33]2)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>>[CH2:23]([N:30]1[CH2:35][C@@H:34]2[CH2:36][C@H:31]1[CH2:32][N:33]2[C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1