huagongshe.com
HRID624927

反应详情

EQUATION

反应方程式

HRID 624927 的结构方程式

REACTANTS

反应物

4
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：C1O[C@@H]2CN[C@H]1C2.Cl
HCID21303398

(1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane hydrochloride (1:1)

C5H10ClNO

结构：O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
HCID71087292

未命名化合物

PRODUCTS

生成物

1
结构：O=C(c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)N1C[C@@H]2C[C@H]1CO2
HCID118451443

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane hydrochloride (31560-06-2) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=366.5 [MH+].