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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 624930생성일: 2026년 10월 25일

4,4-Difluoro-L-prolinamide hydrochloride → (S)-1-(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-4,4-difluoro-pyrrolidine-2-carboxylic acid amide

https://huagongshe.com/reaction/624930

반응식

참여 물질

역할이름HCID투입량
반응물4,4-Difluoro-L-prolinamide hydrochlorideHCID 45158909—
반응물5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 71087346—
생성물(S)-1-(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-4,4-difluoro-pyrrolidine-2-carboxylic acid amideHCID 90203444—

반응 단계

The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 50 mg, 214 μmol) and (2S)-4,4-difluoro-2-pyrrolidinecarboxamide hydrochloride (CAN 426844-51-1; 44 mg, 236 μmol) as starting materials and isolated (63 mg, 80%) as off-white solid; LC-MS (UV peak area, ESI) 100%, 366.1629 [MH+].

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09303012B2
출처 데이터셋uspto-grants-2016_04
ORD IDord-5370fd473c0c4aae87d5618f1306a32c
출처 메모uspto-grants-2016_04