huagongshe.com
HRID624940

反应详情

EQUATION

反应方程式

HRID 624940 的结构方程式

REACTANTS

反应物

4
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：Cl.NC(=O)[C@@H]1C[C@H](F)CN1
HCID45158917

(4S)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1)

C5H10ClFN2O

结构：O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
HCID71087292

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)[C@@H]1C[C@H](F)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
HCID118451449

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with (2S,4S)-4-fluoropyrrolidine-2-carboxamide hydrochloride (426844-23-7) in the presence of TBTU and DIEA to obtain the title compound as white solid; MS (EI): m/e=399.4 [MH+].