HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine-3-carboxamide → 4-(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-thiomorpholine-3-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine-3-carboxamide | HCID 568316 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 71087346 | — |
| Product | 4-(5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carbonyl)-thiomorpholine-3-carboxylic acid amide | HCID 76280802 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 100 mg, 429 μmol) and 3-thiomorpholinecarboxamide (CAN 103742-31-0, 68.9 mg, 472 μmol) as starting materials and isolated (119 mg, 77%) as white solid; LC-MS (UV peak area, ESI) 100%, 362.1540 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-484fb3d14ac34d3f85455aaa12b4075d |
| Source note | uspto-grants-2016_04 |