5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → HCID 76280803, compound

HRID 624957Notes

Reaction equation

HRID 624957 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[CH3:19][C:20]1([CH3:28])[CH2:24][NH:23][CH:22]([C:25]([NH2:27])=[O:26])[CH2:21]1>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([N:23]3[CH2:24][C:20]([CH3:28])([CH3:19])[CH2:21][CH:22]3[C:25]([NH2:27])=[O:26])=[O:17])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 90203546HCID 90203546, compound

Product 1

HCID 76280803HCID 76280803, compound

Procedure

The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 100 mg, 429 μmol) and 4,4-dimethyl-pyrrolidine-2-carboxylic acid amide hydrochloride (84.3 mg, 472 μmol) as starting materials and isolated (145 mg, 95%) as white foam; LC-MS (UV peak area, ESI) 100%, 358.2124 [MH+].

Workup

  1. customisolated (145 mg, 95%) as white foam

Sources & evidence

ORD record
ord-43e3b11020374179bb8689e298bc2162
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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