HRID624969

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

HCID12223519

Methyl pyrrolidine-2-carboxylate hydrochloride

C6H12ClNO2

结构：O=C(O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1

HCID71087292

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1CCCN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1

HCID90203624

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 47 b), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b)) was reacted with methyl pyrrolidine-2-carboxylate hydrochloride (79397-50-5) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=396.5 [MH+].