HRID624971

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

HCID25212666

tert-Butyl 1,8-diazaspiro[4.5]decane-8-carboxylate

C13H24N2O2

HCID71087698

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC2(CCCN2C(=O)c2ccc(C3CC3)c(Cc3ccc(F)cc3)n2)CC1

HCID90203564

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 5 g)) was reacted with tert-butyl 1,8-diazaspiro[4.5]decane-8-carboxylate (937729-06-1) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=494.6 [MH+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fe0f3f04c28b4565a4020c81ef8b0ffb
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09303012B2
来源说明: uspto-grants-2016_04

反应 SMILES

[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.[NH:21]1[C:25]2([CH2:30][CH2:29][N:28]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:27][CH2:26]2)[CH2:24][CH2:23][CH2:22]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>>[C:34]([O:33][C:31]([N:28]1[CH2:27][CH2:26][C:25]2([N:21]([C:18]([C:7]3[CH:6]=[CH:5][C:4]([CH:1]4[CH2:2][CH2:3]4)=[C:9]([CH2:10][C:11]4[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=4)[N:8]=3)=[O:20])[CH2:22][CH2:23][CH2:24]2)[CH2:30][CH2:29]1)=[O:32])([CH3:37])([CH3:35])[CH3:36]