Hydrochloric Acid → HCID 90203486, compound

HRID 624977Notes

Reaction equation

HRID 624977 reaction equation
[C:1]([C@@H:4]1[C:8]([CH3:10])([CH3:9])[S:7][CH2:6][N:5]1C(OC(C)(C)C)=O)(=[O:3])[NH2:2].[ClH:18]>O1CCOCC1>[ClH:18].[CH3:9][C:8]1([CH3:10])[S:7][CH2:6][NH:5][C@@H:4]1[C:1]([NH2:2])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90203789HCID 90203789, compound

Product 1

HCID 90203486HCID 90203486, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure described in Example 82 a), (R)-tert-butyl 4-carbamoyl-5,5-dimethylthiazolidine-3-carboxylate was treated with a 4 M solution of HCl in dioxane to give the title compound as yellow solid which was sufficiently pure to be used in the next step; MS (EI): m/e=161.2 [(M-Cl)H+].

Sources & evidence

ORD record
ord-e5926f65151c467f985b2a79efd3bb98
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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