HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1) → HCID 90203522, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R)-4-Fluoro-L-prolinamide--hydrogen chloride (1/1) | HCID 67034973 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 71087346 | — |
| Product | HCID 90203522 | HCID 90203522 | 73% |
Reaction Steps
In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 3 c, 50 mg, 214 μmol) was reacted with (2S,4R)-4-fluoropyrrolidine-2-carboxamide hydrochloride (CAN 796884-06-5, 39.8 mg, 236 μmol) to obtain the title compound (54 mg, 73%) as white solid; LC-MS (UV peak area, ESI) 100%, 348.1727 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-cb59dc8449a745ff92a2550c1af58f61 |
| Source note | uspto-grants-2016_04 |