HRID624997

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID45158909

4,4-Difluoro-L-prolinamide--hydrogen chloride (1/1)

C5H9ClF2N2O

HCID90202607

未命名化合物

PRODUCTS

生成物

结构：NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(C2(F)CCC2)c(OCC2CC2)n1

HCID90203864

未命名化合物

收率 91%

PROCEDURE

实验过程

In analogy to the procedure described in Example 127 e), 6-(cyclopropylmethoxy)-5-(1-fluorocyclobutyl)pyridine-2-carboxylic acid (Example 130 f, 20 mg, 49.8 μmol) was reacted with (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 426844-51-1, 11.1 mg, 59.7 μmol) to give the title compound (18 mg, 91%) as off-white solid, MS (EI): m/e=398.4 [MH+].