Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,4-Difluoro-L-prolinamide hydrochloride → (2S)-1-[6-(Cyclopropylmethoxy)-5-(1-fluorocyclobutyl)pyridine-2-carbonyl]-4,4-difluoropyrrolidine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,4-Difluoro-L-prolinamide hydrochloride | HCID 45158909 | — |
| 반응물 | 6-(Cyclopropylmethoxy)-5-(1-fluorocyclobutyl)pyridine-2-carboxylic acid | HCID 90202607 | — |
| 생성물 | (2S)-1-[6-(Cyclopropylmethoxy)-5-(1-fluorocyclobutyl)pyridine-2-carbonyl]-4,4-difluoropyrrolidine-2-carboxamide | HCID 90203864 | 91% |
반응 단계
In analogy to the procedure described in Example 127 e), 6-(cyclopropylmethoxy)-5-(1-fluorocyclobutyl)pyridine-2-carboxylic acid (Example 130 f, 20 mg, 49.8 μmol) was reacted with (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 426844-51-1, 11.1 mg, 59.7 μmol) to give the title compound (18 mg, 91%) as off-white solid, MS (EI): m/e=398.4 [MH+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09303012B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-8d7db6ea59e54dee96804538cdfcfceb |
| 출처 메모 | uspto-grants-2016_04 |