(3aR,6aS)-rel-Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride → HCID 90203762, compound

HRID 625018Notes

Reaction equation

HRID 625018 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.Cl.[CH2:22]1[C@@H:26]2[CH2:27][NH:28][CH2:29][C@@H:25]2[CH2:24][O:23]1>>[CH2:22]1[C@@H:26]2[CH2:27][N:28]([C:12]([C:10]3[CH:9]=[CH:8][C:7]([N:15]4[CH2:18][C:17]([F:20])([F:19])[CH2:16]4)=[C:6]([O:5][CH2:4][CH:1]4[CH2:2][CH2:3]4)[N:11]=3)=[O:14])[CH2:29][C@@H:25]2[CH2:24][O:23]1

Participants

3

Reactant 2

HCID 66584117(3aR,6aS)-rel-Hexahydro-1H-furo[3,4-c]pyrrole hydrochlorideHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 90203762HCID 90203762, compoundYield 55%

Procedure

In analogy to the procedure described in Example 127 e), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 30 mg, 106 μmol) was reacted with (3aR,6aS)-hexahydro-1H-furo[3,4-c]pyrrole hydrochloride (CAN 57710-36-8, 15.8 mg, 106 μmol) to obtain the title compound (22 mg, 55%) as white solid, MS (EI): m/e=380.3 [MH+].

Sources & evidence

ORD record
ord-07c016441a42412ebdf96dbbdb6c4b7d
Source dataset
uspto-grants-2016_04
Patent number
US09303012B2

Reaction notes

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