HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3aR,6aS)-rel-Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride → HCID 90203762, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3aR,6aS)-rel-Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride | HCID 66584117 | — |
| Reactant | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid | HCID 71087292 | — |
| Product | HCID 90203762 | HCID 90203762 | 55% |
Reaction Steps
In analogy to the procedure described in Example 127 e), 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 1 b, 30 mg, 106 μmol) was reacted with (3aR,6aS)-hexahydro-1H-furo[3,4-c]pyrrole hydrochloride (CAN 57710-36-8, 15.8 mg, 106 μmol) to obtain the title compound (22 mg, 55%) as white solid, MS (EI): m/e=380.3 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-07c016441a42412ebdf96dbbdb6c4b7d |
| Source note | uspto-grants-2016_04 |