反应详情

In analogy to the procedure described in Example 1 a), methyl 5-bromo-6-(2-fluoroethoxyl)pyridine-2-carboxylate (Example 147 a, 130 mg, 467 μmol) was reacted with 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7, 66.6 mg, 514 μmol) in the presence of palladium (II) acetate, 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl and cesium carbonate to give the title compound (73 mg, 54%) as light yellow solid, MS (ESI) m/e=291.1 [MH+].