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HRID625022

反应详情

EQUATION

反应方程式

HRID 625022 的结构方程式

REACTANTS

反应物

2
结构：Cl.NC(=O)[C@@H]1CC(F)(F)CN1
HCID45158909

4,4-Difluoro-L-prolinamide--hydrogen chloride (1/1)

C5H9ClF2N2O

结构：O=C(O)c1ccc(N2CC(F)(F)C2)c(OCCF)n1
HCID90203920

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)[C@@H]1CC(F)(F)CN1C(=O)c1ccc(N2CC(F)(F)C2)c(OCCF)n1
HCID76281603

未命名化合物

收率 43.3%

PROCEDURE

实验过程

In analogy to the procedure described in Example 127 e), 5-(3,3-difluoroazetidin-1-yl)-6-(2-fluoroethoxyl)pyridine-2-carboxylic acid (Example 147 c, 25 mg, 90.5 μmol) was reacted with (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 426844-51-1, 20.3 mg, 109 μmol) to obtain the title compound (16 mg, 43%) as off-white solid, MS (ESI): m/e=409.1304 [MH+].