Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,4-Difluoro-L-prolinamide hydrochloride → (2S)-1-[5-(3,3-Difluoroazetidin-1-yl)-6-(2-fluoroethoxy)pyridine-2-carbonyl]-4,4-difluoro-pyrrolidine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,4-Difluoro-L-prolinamide hydrochloride | HCID 45158909 | — |
| 반응물 | 5-(3,3-Difluoroazetidin-1-yl)-6-(2-fluoroethoxyl)pyridine-2-carboxylic acid | HCID 90203920 | — |
| 생성물 | (2S)-1-[5-(3,3-Difluoroazetidin-1-yl)-6-(2-fluoroethoxy)pyridine-2-carbonyl]-4,4-difluoro-pyrrolidine-2-carboxamide | HCID 76281603 | 43.3% |
반응 단계
In analogy to the procedure described in Example 127 e), 5-(3,3-difluoroazetidin-1-yl)-6-(2-fluoroethoxyl)pyridine-2-carboxylic acid (Example 147 c, 25 mg, 90.5 μmol) was reacted with (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 426844-51-1, 20.3 mg, 109 μmol) to obtain the title compound (16 mg, 43%) as off-white solid, MS (ESI): m/e=409.1304 [MH+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09303012B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-05b742c0bb3d4e2c84f1c1ba12aeddb6 |
| 출처 메모 | uspto-grants-2016_04 |