Hydrochloric Acid → (S)-5-methyl-4-((S)-2-methylpiperazin-1-yl)-5,7-dihydrothieno[3,4-d]pyrimidine

Participants

Reaction Steps

To a solution of (S)-tert-butyl 3-methyl-4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate (2 g, 5.71 mmol) in DCM (20 mL) was added HCl (4M in dioxane, 6 mL). The mixture was stirred at room temperature overnight. The solvent was removed to afford (S)-5-methyl-4-((S)-2-methylpiperazin-1-yl)-5,7-dihydrothieno[3,4-d]pyrimidine (2.0 g, 99%). MS (APCI+) [M+H]+ 251.

Provenance & Evidence