Hydrochloric Acid → HCID 67459798, compound

HRID 625040Notes

Reaction equation

HRID 625040 reaction equation
[CH3:1][C@@H:2]1[N:7]([C:8]2[C:9]3[C@H:16]([CH3:17])[S:15][CH2:14][C:10]=3[N:11]=[CH:12][N:13]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.Cl>C(Cl)Cl>[CH3:17][C@H:16]1[C:9]2[C:8]([N:7]3[CH2:6][CH2:5][NH:4][CH2:3][C@@H:2]3[CH3:1])=[N:13][CH:12]=[N:11][C:10]=2[CH2:14][S:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67457711HCID 67457711, compound

Product 1

HCID 67459798HCID 67459798, compoundYield 139.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-tert-butyl 3-methyl-4-((S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate (2 g, 5.71 mmol) in DCM (20 mL) was added HCl (4M in dioxane, 6 mL). The mixture was stirred at room temperature overnight. The solvent was removed to afford (S)-5-methyl-4-((S)-2-methylpiperazin-1-yl)-5,7-dihydrothieno[3,4-d]pyrimidine (2.0 g, 99%). MS (APCI+) [M+H]+ 251.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-77005611e09840a6b0aa2de376362290
Source dataset
uspto-grants-2016_04
Patent number
US09303040B2

Reaction notes

Loading…