Hydrochloric Acid → Hydrochloric Acid

HRID 625050Notes

Reaction equation

HRID 625050 reaction equation
[N:1]1[C:6]2[CH2:7][S:8][CH2:9][C:5]=2[C:4]([N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[N:3][CH:2]=1.[ClH:23]>C(Cl)Cl>[N:10]1([C:4]2[C:5]3[CH2:9][S:8][CH2:7][C:6]=3[N:1]=[CH:2][N:3]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[ClH:23]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67457495HCID 67457495, compound

Product 2

HCID 313Hydrochloric AcidYield 99%HCID 67459054HCID 67459054, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-(5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate (0.41 g, 1.3 mmol) in CH2Cl2 (20 mL) was added HCl (4M in dioxane, 5 mL). The mix was stirred at room temperature for 4 hours. The solvent was removed to afford 4-(piperazin-1-yl)-5,7-dihydrothieno[3,4-d]pyrimidine as HCl salt (0.28 g, 99%). MS (APCI+) [M+H]+ 223.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-3d93226bb60b489891d258d9239f234c
Source dataset
uspto-grants-2016_04
Patent number
US09303040B2

Reaction notes

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