Hydrochloric Acid → HCID 24949763, compound

Participants

Reaction Steps

To a solution of (R)-tert-butyl 3-(4-chlorophenyl)-1-(4-(5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate (30 mg, 0.06 mmol) in CH2Cl2 (10 mL) was added HCl (4M in dioxane, 2 mL). The mixture was stirred at room temperature for 4 hours. The solvent was removed to afford (R)-2-amino-3-(4-chlorophenyl)-1-(4-(5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one dihydrochloride (30 mg, 99%). MS (APCI+) [M+H]+ 405.

Provenance & Evidence