Hydrochloric Acid → HCID 24949763, compound

HRID 625052Notes

Reaction equation

HRID 625052 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@@H:9]([NH:27]C(=O)OC(C)(C)C)[C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:19]4[CH2:26][S:25][CH2:24][C:20]=4[N:21]=[CH:22][N:23]=3)[CH2:14][CH2:13]2)=[O:11])=[CH:4][CH:3]=1.[ClH:35]>C(Cl)Cl>[ClH:1].[ClH:35].[NH2:27][C@H:9]([CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[C:19]3[CH2:26][S:25][CH2:24][C:20]=3[N:21]=[CH:22][N:23]=2)[CH2:14][CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67459937HCID 67459937, compound

Product 1

HCID 24949763HCID 24949763, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (R)-tert-butyl 3-(4-chlorophenyl)-1-(4-(5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)-1-oxopropan-2-ylcarbamate (30 mg, 0.06 mmol) in CH2Cl2 (10 mL) was added HCl (4M in dioxane, 2 mL). The mixture was stirred at room temperature for 4 hours. The solvent was removed to afford (R)-2-amino-3-(4-chlorophenyl)-1-(4-(5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one dihydrochloride (30 mg, 99%). MS (APCI+) [M+H]+ 405.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-0d01092238de4a6594e2d5c373455f24
Source dataset
uspto-grants-2016_04
Patent number
US09303040B2

Reaction notes

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