Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of (R)-tert-butyl 4-(5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate (prepared according to Example 1, Steps 1-5) (1.05 g, 3.12 mmol) in CH2Cl2 (20 mL) was added HCl (4M, in dioxane, 4 mL). The mixture was stirred at room temperature overnight. The solvent was removed to afford (R)-5-methyl-4-(piperazin-1-yl)-5,7-dihydrothieno[3,4-d]pyrimidine as HCl salt (0.74 g, 99%). MS (APCI+) [M+H]+ 237.

Provenance & Evidence