Hydrochloric Acid → Hydrochloric Acid

HRID 625053Notes

Reaction equation

HRID 625053 reaction equation
[CH3:1][C@@H:2]1[C:10]2[C:9]([N:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)=[N:8][CH:7]=[N:6][C:5]=2[CH2:4][S:3]1.[ClH:24]>C(Cl)Cl>[CH3:1][C@@H:2]1[C:10]2[C:9]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[N:8][CH:7]=[N:6][C:5]=2[CH2:4][S:3]1.[ClH:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67459112HCID 67459112, compound

Product 2

HCID 313Hydrochloric AcidYield 99%HCID 67458991HCID 67458991, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (R)-tert-butyl 4-(5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylate (prepared according to Example 1, Steps 1-5) (1.05 g, 3.12 mmol) in CH2Cl2 (20 mL) was added HCl (4M, in dioxane, 4 mL). The mixture was stirred at room temperature overnight. The solvent was removed to afford (R)-5-methyl-4-(piperazin-1-yl)-5,7-dihydrothieno[3,4-d]pyrimidine as HCl salt (0.74 g, 99%). MS (APCI+) [M+H]+ 237.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-c989f067f4d3496d8ca1c7134c4049f5
Source dataset
uspto-grants-2016_04
Patent number
US09303040B2

Reaction notes

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