Sodium Iodide → 5-(4-Methoxy-3-(2-oxo-2-(2-oxo-2-(2-oxo-2-((2-phenylpropan-2-yl)oxy)ethoxy)ethoxy)ethyl)phenyl)-dibenzothiophenium chloride

Participants

Reaction Conditions

Reaction Steps

5-(3-(2-(carboxymethoxy)-2-oxoethyl)-4-methoxyphenyl)dibenzothiophenium chloride (25 g, 59.2 mmol), 2-phenylpropan-2-yl 2-bromoacetate (15.2 g, 59.2 mmol), sodium iodide (17.7 g, 0.118 mmol), and cesium carbonate (38.4 g, 0.118 mmol) are dissolved in DMF (200 mL) and stirred at 25° C. for 4 h. The reaction mixture is quenched with water (500 mL), extracted with DCM (2×200 mL), the combined organic layers washed with water (4×200 mL), concentrated to a viscous oil and precipitated from MTBE (1 L) to afford the title compound as a white solid.

Provenance & Evidence