反应详情

温度

25 °C

5-(3-(2-(carboxymethoxy)-2-oxoethyl)-4-methoxyphenyl)dibenzothiophenium chloride (25 g, 59.2 mmol), 2-phenylpropan-2-yl 2-bromoacetate (15.2 g, 59.2 mmol), sodium iodide (17.7 g, 0.118 mmol), and cesium carbonate (38.4 g, 0.118 mmol) are dissolved in DMF (200 mL) and stirred at 25° C. for 4 h. The reaction mixture is quenched with water (500 mL), extracted with DCM (2×200 mL), the combined organic layers washed with water (4×200 mL), concentrated to a viscous oil and precipitated from MTBE (1 L) to afford the title compound as a white solid.

1. customThe reaction mixture is quenched with water (500 mL)
2. extractionextracted with DCM (2×200 mL)
3. washthe combined organic layers washed with water (4×200 mL)
4. concentrationconcentrated to a viscous oil
5. customprecipitated from MTBE (1 L)