反应详情

温度

25 °C

A solution of 100 mg of N-(2-chloroethyl)morpholine and 307 mg of cyclopropylamine in 5 mL of CH3CN was refluxed for 2 h. The mixture was cooled to 25° C. and treated with excess K2CO3. After stirring for 1 h the suspension was filtered and the solvent was evaporated. The residual solvent was removed at high vacuum and the residue was dissolved in a large excess of methanolic HCl. The solvent was evaporated to give 102 mg of the product.

1. filtrationwas filtered
2. customthe solvent was evaporated
3. customThe residual solvent was removed at high vacuum
4. dissolutionthe residue was dissolved in a large excess of methanolic HCl
5. customThe solvent was evaporated