反应详情

A solution of 50 mg of 4-ethynyl-2-(2-nitro-5-(piperidin-1-yl)phenyl)pyridine, 20 μL of benzyl azide, 16.3 μL of 1 M aqueous sodium ascorbate solution, 5.4 μL of 0.3 M CuSO4 solution, 326 μL of tert-butanol, and 326 μL of water was stirred for 2 days and then the solvent was evaporated at reduced pressure. The residue was dissolved in dichloromethane. The solution was washed with water and dried. The solvent was evaporated at reduced pressure and the residue was chromatographed on silica gel eluting with a 0% to 4% gradient of methanol in dichloromethane. The process yielded 22 mg of product.

1. customthe solvent was evaporated at reduced pressure
2. dissolutionThe residue was dissolved in dichloromethane
3. washThe solution was washed with water
4. customdried
5. customThe solvent was evaporated at reduced pressure
6. customthe residue was chromatographed on silica gel eluting with a 0% to 4% gradient of methanol in dichloromethane