Hydrochloric Acid → HCID 66586873, compound

HRID 625450Notes

Reaction equation

HRID 625450 reaction equation
[CH2:1]([N:3]([CH2:46][CH3:47])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=2)[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12])=[C:6]([C:26]2[CH:31]=[C:30]([C:32](=[O:45])[NH:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[CH:36]=3)[CH:29]=[CH:28][N:27]=2)[CH:5]=1)[CH3:2].Cl>O1CCOCC1>[CH2:46]([N:3]([CH2:1][CH3:2])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=2)[C:16]([OH:18])=[O:17])=[O:12])=[C:6]([C:26]2[CH:31]=[C:30]([C:32](=[O:45])[NH:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:42])([F:43])[F:44])[CH:36]=3)[CH:29]=[CH:28][N:27]=2)[CH:5]=1)[CH3:47]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66586978HCID 66586978, compound

Product 1

HCID 66586873HCID 66586873, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-((4-(diethylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)benzoate was added 4M HCl in dioxane (25 mL). The mixture was stirred at room temperature for 3 hours, concentrated to give a light yellow solid which was used without further purification.

Workup

  1. concentrationconcentrated
  2. customto give a light yellow solid which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-11a567f117b443c4a287bb83971a5f24
Source dataset
uspto-grants-2016_04
Patent number
US09301951B2

Reaction notes

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