HRID625450

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCN(CC)c1ccc(NC(=O)c2cccc(C(=O)OC(C)(C)C)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1

HCID66586978

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)c1ccc(NC(=O)c2cccc(C(=O)O)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1

HCID66586873

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To tert-butyl 3-((4-(diethylamino)-2-(4-((3-(trifluoromethyl)benzyl)carbamoyl)pyridin-2-yl)phenyl)carbamoyl)benzoate was added 4M HCl in dioxane (25 mL). The mixture was stirred at room temperature for 3 hours, concentrated to give a light yellow solid which was used without further purification.

WORKUP

后处理

concentrationconcentrated
customto give a light yellow solid which
customwas used without further purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-11a567f117b443c4a287bb83971a5f24
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09301951B2
来源说明: uspto-grants-2016_04

反应 SMILES

[CH2:1]([N:3]([CH2:46][CH3:47])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=2)[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12])=[C:6]([C:26]2[CH:31]=[C:30]([C:32](=[O:45])[NH:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[CH:36]=3)[CH:29]=[CH:28][N:27]=2)[CH:5]=1)[CH3:2].Cl>O1CCOCC1>[CH2:46]([N:3]([CH2:1][CH3:2])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=2)[C:16]([OH:18])=[O:17])=[O:12])=[C:6]([C:26]2[CH:31]=[C:30]([C:32](=[O:45])[NH:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:42])([F:43])[F:44])[CH:36]=3)[CH:29]=[CH:28][N:27]=2)[CH:5]=1)[CH3:47]