反应详情

温度

65 °C

To a solution of 4.47 mmol of 1-benzyl-7-methoxy-3,4-dihydronaphthalen-2(1H)-one in 15 ml ethanol were added 5.59 mmol hydroxylamine hydrochloride (dissolved in 3 ml water). The solution was stirred at 65° C. for 1.5 h. The mixture was cooled to RT and concentrated. The residue was dissolved in methyl tert-butylether and washed with water (2×), dried over MgSO4 and filtered. Evaporation of the solvent gave 1.29 g of 1-benzyl-7-methoxy-3,4-dihydronaphthalen-2(1H)-one oxime (mixture of E- and Z-isomer, 100%).

1. temperatureThe mixture was cooled to RT
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in methyl tert-butylether
4. washwashed with water (2×)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customEvaporation of the solvent