反应详情

A mixture containing 2-methoxy-4-propylphenol (0.625 mmol; 100 μl), copper(II) acetate (0.625 mmol; 114 mg), 4-methoxyphenylboronic acid (1.25 mmol; 190 mg), triethylamine (3.12 mmol; 0.43 ml), some crushed molecular sieves 4 Å in dichloromethane (3 ml) was stirred at rt under air for 24 h. The residue is filtered with chloroform on Celite. The organic phase is washed with saturated NH4Cl, saturated NaHCO3 and brine. After drying (MgSO4), concentration and purification by preparative TLC on silica gel (ethyl acetate/cyclohexane—20/80), the title compound is collected as a colorless oil (70 mg; 0.26 mmol; 41%).

1. filtrationThe residue is filtered with chloroform on Celite
2. washThe organic phase is washed with saturated NH4Cl, saturated NaHCO3 and brine
3. customAfter drying
4. concentration(MgSO4), concentration and purification by preparative TLC on silica gel (ethyl acetate/cyclohexane—20/80)
5. customthe title compound is collected as a colorless oil (70 mg; 0.26 mmol; 41%)