反应详情

温度

80 °C

To a solution of sodium (55 mg; 2.39 mmol), under argon, in ethanol (2 mL), was added 2-(4-ethyl-2-methoxyphenoxy)-6-fluoropyridine (82 mg; 0.33 mmol). The reaction was heated to 80° C. for 16 hours then to 90° C. for 26 hours. The mixture was concentrated in vacuo. After quenching with saturated NaHCO3 (10 mL), extractions with ethyl acetate (3*5 mL), the organic phase was dried over NaSO4, and concentrated in vacuo to give the desired product as a light brown oil used without further purification (82 mg; 0.30 mmol; 90%).

1. concentrationThe mixture was concentrated in vacuo
2. customAfter quenching with saturated NaHCO3 (10 mL), extractions with ethyl acetate (3*5 mL)
3. dry with materialthe organic phase was dried over NaSO4
4. concentrationconcentrated in vacuo