Sodium Hydroxide → 3-Ethoxybicyclo[1.1.1]pentan-1-amine

HRID 62602Notes

Reaction equation

HRID 62602 reaction equation
[CH2:1]([O:3][C:4]12[CH2:8][C:6]([NH:9]C(=O)C)([CH2:7]1)[CH2:5]2)[CH3:2].[OH-].[Na+]>>[CH2:1]([O:3][C:4]12[CH2:8][C:6]([NH2:9])([CH2:7]1)[CH2:5]2)[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86287954N-{3-ethoxybicyclo[1.1.1]pentan-1-yl}acetamide

Product 1

HCID 862880253-Ethoxybicyclo[1.1.1]pentan-1-amine

Procedure

Hydrolysis of N-(3-ethoxybicyclo[1.1.1]pentan-1-yl)acetamide (2) with sodium hydroxide (or basic aqueous conditions) gives 3-ethoxybicyclo[1.1.1]pentan-1-amine (6) (Scheme 5).

Sources & evidence

ORD record
ord-312f84ba468849ce8adaf8e1d92ce761
Source dataset
uspto-grants-2016_09
Patent number
US09447025B2

Reaction notes

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